KMID : 0941820180280040293
|
|
Korean Journal of Clinical Pharmacy 2018 Volume.28 No. 4 p.293 ~ p.299
|
|
Comparison of Adverse Events between High-intensity and Moderate- to Low-intensity Statin Group
|
|
Lee Se-Ra
Ock Mi-Young Kim Hyun-Ah
|
|
Abstract
|
|
|
Background: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) effectively reduce serum levels of low-densitylipoprotein (LDL) and total cholesterol. High-intensity statins are recommended for all patients aged ¡Â75 with clinical atheroscleroticcardiovascular disease (ASCVD), diabetes mellitus aged 40-75 with ¡Ã7.5% estimated 10-year ASCVD risk and LDL-C ¡Ã190 mg/dL. High-intensity statins associated with more frequent adverse events (AEs) compared to moderate- to low-intensity statins. Theaim of this study was to compare AEs between high-intensity and moderate- to low-intensity statin group using the Korea AdverseEvent Reporting System (KAERS) database.
Methods: Adults (¡Ã18 years) with statin-associated AEs from July 2009-June 2014were included. Only AEs classified as ¡°certain¡±, ¡°probable¡± and ¡°possible¡± based on the WHO-Uppsala Monitoring Center criteriawere analyzed.
Results: In total, 247 AEs from 196 patients [high-intensity statin group (HG), n = 25 (13%); moderate- to lowintensitystatin group (MLG), n = 171 (87%)] were included. Mean age was higher in HG compared with MLG (67 ¡¾ 14 vs 62 ¡¾ 12).
The HG showed a significant higher frequency of liver/biliary system disorders (37% vs 14%, p = 0.001). Hepatic function abnormalwas reported more frequently in HG compared to MLG (26% vs 9%, p = 0.006).
Conclusion: According to KAERS data, liver/biliarysystem disorders were more frequently reported in HG compared to MLG.
|
|
KEYWORD
|
|
Hydroxymethylglutaryl-CoA reductase inhibitors, KAERS, drug-related side effects, adverse reactions
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|